Influence of Lactobacillus plantarum administration on some serum/tissue (uterus) antioxidant and cytokine levels in female rats exposed to cadmium (Cd)

The study aimed to investigate the effects of oral Lactobacillus plantarum (Lp) administration on some serum/tissue (uterus) antioxidant and cytokine levels as well histopathologic changes in female rats exposed chronically Cd. For this purpose, were separated into four groups including control (C, n = 8), cadmium (Cd, Lp (n Cd + 8). (dissolved water at a dose 2.04 mg/mL) was orally administered for 28 days. Besides, active-live Lp, which grown level approximately 10$^{8}$-10$^{9}$ cfu/mL skim milk powder medium, group animals same Only fresh standard rat food given ad libitum C group. After period, they decapitated samples taken measurement GSH levels, CAT SOD enzyme activities, MDA values, TNF-α, IL-6, IL-1ß, IL-10 changes. Administration suspension decreased accumulation serum compared (p < 0.05). Also, led decrease when In addition, Conversely, we did not determine any significant alterations among regarding tissue IL-10, and, IL-1ß levels. However, uterus TNF-α concentrations higher both groups. activity conclusion, partially protects from harmful chronic toxicity.